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Substance Use and Associated Health Conditions throughout the Lifespan

Public Health Reviews volume 35, Article number: 3 (2013) Cite this article

Abstract

A life stage perspective is necessary for development of age-appropriate strategies to address substance use disorders (SUDs) and related health conditions in order to produce better overall health and well-being. The current review evaluated the literature across three major life stages: adolescence, adulthood, and older adulthood.

Findings: 1) Substance use is often initiated in adolescence, but it is during adulthood that prevalence rates for SUDs peak; and while substance involvement is less common among older adults, the risk for health complications associated with use increases. 2) Alcohol, tobacco, marijuana, and, increasingly, prescription medications, are the most commonly misused substances across age groups; however, the use pattern of these and other drugs and the salient impact vary depending on life stage. 3) In terms of health outcomes, all ages are at risk for overdose, accidental injury, and attempted suicide. Adolescents are more likely to be in vehicular accidents while older adults are at greater risk for damaging falls. Adulthood has the highest rates of associated medical conditions (e.g., cancer, sexually transmitted disease, heart disease) and mental health conditions (e.g., bipolar disorder, anxiety disorders, antisocial personality disorder).

Conclusion: Prolonged heavy use of drugs and/or alcohol results in an array of serious health conditions. Addressing SUDs from a life stage perspective with assessment and treatment approaches incorporating co-occurring disorders are necessary to successfully impact overall health.

References

  1. U.S. Department of Justice, National Drug Intelligence Center. The economic impact of illicit drugs use on American society. Washington (DC): U.S. Department of Justice; April 2011. Available from URL: http://www.justice.gov/archive/ndic/pubs44/44731/44731p.pdf (Accessed 4 February 2014).

    Google Scholar 

  2. Bouchery E, Harwood H, Sacks C, Simon C, Brewer R. Economic costs of excessive alcohol consumption in the U.S., 2006. Am J Prev Med. 2011;41:516–24.

    Article  PubMed  Google Scholar 

  3. Centers for Disease Control and Prevention. Smoking-attributable mortality, years of potential life lost, and productivity losses—United States, 2000–2004. MMWR Morb Mortal Wkly Rep. 2008;57:1226-8. Available from URL: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5745a3.htm (Accessed 16 September 2013).

  4. Steinberg L. A social neuroscience perspective on adolescent risk-taking. Dev Rev. 2008;28:78–106.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Brown SA, Tapert SF. Adolescence and the trajectory of alcohol use: basic to clinical studies. Ann N Y Acad Sci. 2004;1021:234–44.

    Article  PubMed  Google Scholar 

  6. Moore AA, Giuli L, Gould R, Zhou K, Reuben D, et al. Alcohol use, comorbidity, and mortality. J Am Geriatr Soc. 2006;54:757–62.

    Article  PubMed  Google Scholar 

  7. Moore AA, Whiteman EJ, Ward KT. Risks of combined alcohol/medication use in older adults. Am J Geriatr Pharmacother. 2007;5:64–74.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Moos RH, Brennan PL, Schutte KK, Moos BS. High-risk alcohol consumption and late-life alcohol use problems. Am J Pub Health. 2004;94:1985–91.

    Article  Google Scholar 

  9. Baltes PB. Theoretical propositions of life-span developmental psychology: on the dynamics between growth and decline. Develop Psych. 1987;23:611–26.

    Article  Google Scholar 

  10. Bronfenbrenner U. The Ecology of Human Development: Experiments by Nature and Design. Cambridge (MA): Harvard University Press; 1979.

    Google Scholar 

  11. Lerner RM, Kauffman MB. The concept of development in contextualism. Develop Rev. 1985;5:309–33.

    Article  Google Scholar 

  12. Sameroff AJ. The societal context of development. In: Eisenberg N, (editor). Contemporary Topics in Developmental Psychology. New York (NY): Wiley; 1987. p.273–91.

    Google Scholar 

  13. Substance Abuse and Mental Health Services Administration. Results from the 2011 National Survey on Drug Use and Health: summary of national findings. NSDUH Series H-44, HHS Publication No. (SMA) 12-4713. Rockville (MD): Substance Abuse and Mental Health Services Administration; September 2012. Available from URL: http://www.samhsa.gov/data/nsduh/2k11results/nsduhresults2011.pdf (Accessed 4 February 2014).

    Google Scholar 

  14. Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. Treatment Episode Data Set (TEDS): 2000–2010. National admissions to substance abuse treatment services. DASIS Series S-61, HHS Publication No. (SMA) 12-4701. Rockville (MD): Substance Abuse and Mental Health Services Administration; June 2012. Available from URL: http://www.samhsa.gov//data/2k12/TEDS2010N/TEDS2010NWeb.pdf (Accessed 4 February 2014).

    Google Scholar 

  15. Menninger JA. Assessment and treatment of alcoholism and substance-related disorders in the elderly. B Menninger Clin. 2002;66:166–84.

    Article  Google Scholar 

  16. Hser YI, Hoffman V, Grella CE, Anglin D. A 33-year follow-up of narcotics addicts. Arch Gen Psychiatry. 2001;58:503–8.

    Article  CAS  PubMed  Google Scholar 

  17. Johnston LD, O’Malley PM, Bachman JG, Schulenberg JE. Monitoring the Future national results on adolescent drug use: overview of key findings, 2011. Ann Arbor (MI): Institute for Social Research, University of Michigan; February 2012. Available from URL: http://www.monitoringthefuture.org/pubs/monographs/mtf-overview2011.pdf (Accessed 4 February 2014).

    Google Scholar 

  18. Friedman HL. Adolescent and social development: a global perspective. J Adolesc Health. 1993;14:588–94.

    Article  CAS  PubMed  Google Scholar 

  19. Jessor R. Adolescent development and behavioral health. In: Matarazzo JD, Perry CL, (editors). Behavioral Health: A Handbook of Health Enhancement and Disease Prevention. New York (NY): Wiley; 1984. p.69–90.

    Google Scholar 

  20. Peterson AC, Leffert N, Graham B, Alwin J, Ding A. Promoting mental health during the transition to adolescence. In: Schulenberg J, Maggs JL, Hurrelmann K, (editors). Health Risks and Developmental Transitions during Adolescence. New York (NY): Cambridge University Press; 1997. p.471–97.

    Google Scholar 

  21. Centers for Disease Control and Prevention. Youth risk behavior surveillance — United States 2011. MMWR Surveill Summ. 2012;61:1–162.

    Google Scholar 

  22. Arria AM, Garnier-Dykstra LM, Caldeira KM, Vincent KB, O’Grady KE, Wish ED. Persistent nonmedical use of prescription stimulants among college students: possible association with ADHD symptoms. J Attention Disorders, 2011;15:347–56.

    Article  Google Scholar 

  23. Berenson AB, Wiemann CM, McCombs S. Exposure to violence and associated health-risk behaviors among adolescent girls. Arch Pediatr Adolesc Med. 2001;155:1238–42.

    Article  CAS  PubMed  Google Scholar 

  24. Centers for Disease Control and Prevention. Vital signs: HIV infection, testing, and risk behavior among youths — United States. MMWR Morb Mortal Wkly Rep. 2012;61:971–6.

    Google Scholar 

  25. Kingree JB, Braithwaite R, Woodring T. Unprotected sex as a function of alcohol and marijuana use among adolescent detainees. J Adolesc Health. 2000;27:179–85.

    Article  CAS  PubMed  Google Scholar 

  26. Lowry R, Holtzman D, Truman BI, Kann L, Collins JL, Kolbe LJ. Substance use and HIV-related sexual behaviors among US high school students: are they related? Am J Pub Health. 1994;84:1116–20.

    Article  CAS  Google Scholar 

  27. Leigh BC, Stall R. Substance use and risky sexual behavior for exposure to HIV: issues in methodology, interpretation, and prevention. Am Psychol. 1993;48:1035–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Riehman KS, Wechsberg WM, Francis SA, Moore M, Morgan-Lopez A. Discordance in monogamy beliefs, sexual concurrency, and condom use among young adult substance-involved couples: implications for risk of sexually transmitted infections. Sex Transm Dis. 2006;33:677–82.

    Article  PubMed  Google Scholar 

  29. Tapert SF, Aarons GA, Sedlar GR, Brown SA. Adolescent substance use and sexual risk-taking behavior. J Adolesc Health. 2001;28:181–9.

    Article  CAS  PubMed  Google Scholar 

  30. Yan AF, Chiu YW, Stoesen CA, Wang MQ. STD-/HIV-related sexual risk behaviors and substance use among US rural adolescents. J Nat Med Assoc. 2007;99:1386–94.

    Google Scholar 

  31. Botvin GJ, Griffin KW, Diaz T, Ifill-Williams M. Drug abuse prevention among minority adolescents: one-year follow-up of a school-based prevention intervention. Prev Sci. 2001;2:1–13.

    Article  CAS  PubMed  Google Scholar 

  32. Substance Abuse and Mental Health Services Administration. Drug Abuse Warning Network, 2011: national estimates of drug-related emergency department visits. HHS Publication No. (SMA) 13-4760, DAWN Series D-39. Rockville (MD): Substance Abuse and Mental Health Services Administration; May 2013. Available from URL: http://www.samhsa.gov/data/2k13/DAWN2k11ED/DAWN2k11ED.htm (Accessed 4 February 2014).

    Google Scholar 

  33. Mertens JR, Flisher AJ, Fleming MF, Weisner CM. Medical conditions of adolescents in alcohol and drug treatment: comparison with matched controls. J Adolesc Health. 2007;40:173–9.

    Article  PubMed  Google Scholar 

  34. Myers MG, Brown SA. Smoking and health in substance abusing adolescents: a two year follow-up. Pediatrics. 1994;93:561–6.

    CAS  PubMed  Google Scholar 

  35. Myers MG, Brown SA. Cigarette smoking four years following treatment for adolescent substance abuse. J Adolesc Subst Abuse. 1997;7:1–15.

    Google Scholar 

  36. Kochanek KD, Kirmeyer SE, Martin JA, Strobino DM, Guyer B. Annual summary of vital statistics: 2009. Pediatrics. 2012;129:338–48.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Martin JA, Kung HC, Mathews TJ, Hoyert DL, Strobino DM, et al. Annual summary of vital statistics: 2006. Pediatrics. 2008;121:788–801.

    Article  PubMed  Google Scholar 

  38. Nock MK, Green JG, Hwang I, McLaughlin KA, Sampson NA, et al. Prevalence, correlates, and treatment of lifetime suicidal behavior among adolescents results from the National Comorbidity Survey Replication Adolescent Supplement. JAMA Psychiatry. 2013;70:300–10.

    Article  PubMed  Google Scholar 

  39. Bukstein OG, Brent DA, Perper JA, Moritz G, Baugher M, et al. Risk factors for completed suicide among adolescents with a lifetime history of substance abuse: a case-control study. Acta Psychiatr Scand. 1993;88:403–8.

    Article  CAS  PubMed  Google Scholar 

  40. Wu P, Hoven CW, Liu X, Cohen P, Fuller CJ, Shaffer D. Substance use, suicidal ideation and attempts in children and adolescents. Suicide Life Threat Behav. 2004;34:408–20.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Storr CL, Pacek LR, Martins SS. Substance use disorders and adolescent psychopathology. Pub Health Rev. 2012;34:442–84. Available from URL: http://www.publichealthreviews.eu/show/p/107 (Accessed 4 February 2014).

    Google Scholar 

  42. Kaminer Y, Bukstein OG, (editors). Adolescent Substance Abuse: Psychiatric Comorbidity and High Risk Behaviors. New York (NY): Taylor and Francis; 2007.

    Google Scholar 

  43. Roberts RE, Roberts CR, Xing Y. Rates of DSM-IV psychiatric disorders among adolescents in a large metropolitan area. J Psych Res. 2007;41:959–67.

    Article  Google Scholar 

  44. Couwenbergh C, van den Brink W, Zwart K, Vreugdenhil C, van Wijngaarden-Cremers P, van der Gaag RJ. Comorbid psychopathology in adolescents and young adults treated for substance use disorders. Eur Child Adolesc Psychiatry. 2006;15:319–28.

    Article  PubMed  Google Scholar 

  45. O’Neil KA, Conner BT, Kendall PC. Internalizing disorders and substance use disorders in youth: comorbidity, risk, temporal order, and implications for intervention. Clin Psychol Rev. 2011;31:104–12.

    Article  PubMed  Google Scholar 

  46. Bukstein OG, Glancy LJ, Kaminer Y. Patterns of affective comorbidity in a clinical population of dually diagnosed adolescent substance abusers. J Am Acad Child Psychiatry. 1992;31:1041–5.

    Article  CAS  Google Scholar 

  47. McGuinness TM, Dyer JG, Wade EH. Gender differences in adolescent depression. J Psychosoc Nurs Ment Health Serv. 2012;50:17–20.

    PubMed  Google Scholar 

  48. Nolen-Hoeksema S. An interactive model for the emergence of gender differences in depression in adolescence. J Research Adolesc. 1994;4:519–34.

    Article  Google Scholar 

  49. Shrier LA, Harris SK, Kurland M, Knight JR. Substance use problems and associated psychiatric symptoms among adolescents in primary care. Pediatrics. 2003;111:699–705.

    Article  Google Scholar 

  50. Biederman J, Wilens T, Mick E, Faraone SV, Weber W, et al. Is ADHD a risk factor for psychoactive substance use disorders? Findings from a four-year prospective follow-up study. J Am Acad Adolesc Psychiatry. 1997;36:21–9.

    Article  CAS  Google Scholar 

  51. Molina BS, Pelham Jr, WE. Childhood predictors of adolescent substance use in a longitudinal study of children with ADHD. J Abnorm Psychol. 2003;112:497–507.

    Article  PubMed  Google Scholar 

  52. Costello EJ, Erkanli A, Federman E, Angold A. Development of psychiatric comorbidity with substance abuse in adolescents: effects of timing and sex. J Clin Child Psychol. 1999;28:298–311.

    Article  CAS  PubMed  Google Scholar 

  53. Zucker RA, Heitzeg MM, Nigg JT. Parsing the undercontrol/disinhibition pathway to substance use disorders: a multilevel developmental problem. Child Dev Perspect. 2011;5:248–55.

    Article  PubMed  PubMed Central  Google Scholar 

  54. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington (DC): The Association; 2000.

    Google Scholar 

  55. Costello EJ, Mustillo S, Erkanli A, Keeler G, Angold A. Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry. 2003;60:837–44.

    Article  PubMed  Google Scholar 

  56. Donovan JE, Jessor R, Costa FM. Adolescent health behavior and conventionality-unconventionality: an extension of problem-behavior therapy. Health Psychol. 1991;10:52–61.

    CAS  PubMed  Google Scholar 

  57. White W. Recovery across the life cycle. Alcohol Treat Q. 2006;24:185–201.

    Article  Google Scholar 

  58. Windle M. A multilevel developmental contextual approach to substance use and addiction. Biosocieties. 2010;5:124–36

    Article  PubMed  Google Scholar 

  59. Paulozzi LJ, Annest J. Unintentional poisoning deaths—United States, 1999–2004. MMWR Morb Mortal Wkly Rep. 2007;56:93–6.

    Google Scholar 

  60. Kertesz SG, Pletcher MJ, Safford M, Halanych J, Kirk K, et al. Illicit drug use in young adults and subsequent decline in general health: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Drug Alcohol Depend. 2007;88:224–33.

    Article  PubMed  Google Scholar 

  61. Richter KP, Gibson CA, Ahluwalia JS, Schmelzle KH. Tobacco use and quite attempts among methadone maintenance clients. Am J Pub Health. 2001;91:296–9.

    Article  CAS  Google Scholar 

  62. Hurt RD, Offord KP, Croghan IT, Gomez-Dahl L, Kottke TE, et al. Mortality following inpatient addictions treatment. JAMA. 1996;275:1097–103.

    Article  CAS  PubMed  Google Scholar 

  63. Department of Health and Human Services, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism. Alcohol Alert. Alcohol Res Health. 2007;71:1–6.

    Google Scholar 

  64. National Institute on Drug Abuse. Medical Consequences of Drug Abuse. May 2005. Available from URL: http://www.drugabuse.gov/publications/research-reports/ (Accessed 2 July 2013).

    Google Scholar 

  65. Boffetta P, Hashibe M. Alcohol and cancer. Lancet Oncology. 2006;7:149–56.

    Article  CAS  PubMed  Google Scholar 

  66. Polen MR, Sidney S, Tekawa IS, Sadler M, Friedman GD. Health care use by frequent marijuana smokers who do not smoke tobacco. West J Med. 1993;158:596–601.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Moore BA, Auguston EM, Moser RP, Budney AJ. Respiratory effects of marijuana and tobacco use in a U.S. sample. J Gen Intern Med. 2005;20:33–7.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Kontos MC, Jesse RL, Tatum JL, Ornato JP. Coronary angiographic findings in patients with cocaine-associated chest pain. J Emerg Med. 2003;24:9–13.

    Article  PubMed  Google Scholar 

  69. Chou SP, Grant BF, Dawson DA. Medical consequences of alcohol consumption—United States, 1992. Alcohol Clin Exp Res. 1996;20:1423–9.

    Article  CAS  PubMed  Google Scholar 

  70. Gutjahr E, Gmel G, Rehm JUR. Relation between average alcohol consumption and disease: an overview. Eur Addict Res. 2001;7:117–27.

    Article  CAS  PubMed  Google Scholar 

  71. Xin X, He J, Frontini MG, Ogden LG, Motsamai OI, Whelton PK. Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2001;38:1112–7.

    Article  CAS  PubMed  Google Scholar 

  72. Clark L. Alcohol-induced hypertension: mechanisms, complications, and clinical implications. J Natl Med Assoc. 1985;77:385–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  73. Klatsky AL, Gunderson E. Alcohol and hypertension: a review. J Am Soc Hypertens. 2008;2:307–17.

    Article  PubMed  Google Scholar 

  74. Potter JF, Beevers DG. Pressor effect of alcohol in hypertension. Lancet. 1984;323:119–22.

    Article  Google Scholar 

  75. Hillbom M, Saloheimo P, Juvela S. Alcohol consumption, blood pressure, and the risk of stroke. Curr Hypertens Rep. 2011;13:208–13.

    Article  CAS  PubMed  Google Scholar 

  76. Bourgois P, Lettiere M, Quesada J. Social misery and the sanctions of substance abuse: confronting HIV risk among homeless heroin addicts in San Francisco. Social Problems. 1997;44:155–73.

    Article  Google Scholar 

  77. Koester S, Glanz J, Baron A. Drug sharing among heroin networks: implications for HIV and hepatitis B and C prevention. AIDS Behav. 2005;9:27–39.

    Article  PubMed  Google Scholar 

  78. Koester S, Heimer R, Barón AE, Glanz J, Teng W. RE: “Risk of Hepatitis C virus among young adult injection drug users who share injection equipment”. Am J Epidemiol. 2003;157:376.

    Article  PubMed  Google Scholar 

  79. Centers for Disease Control and Prevention. Drug-associated HIV transmission continues in the United States. Atlanta (GA): CDC; 8 March 2007. Available from URL: http://www.cdc.gov/hiv/resources/factsheets/idu.htm (Accessed 2 July 2013).

    Google Scholar 

  80. Azevedo RCSD, Botega NJ, Guimaraes LAM. Crack users, sexual behavior and risk of HIV infection. Rev Bras Psiquiatr. 2007;29:26–30.

    Article  PubMed  Google Scholar 

  81. Collins CL, Kerr T, Tyndall MW, Marsh DC, Kretz PS, et al. Rationale to evaluate methodically supervised safer smoking facilities for non-injection illicit drug users. Can J Pub Health. 2004;95:344–7.

    Google Scholar 

  82. McCoy CB, Lai S, Metsch LR, Messiah SE, Zhao W. Injection drug use and crack cocaine smoking: independent and dual risk behaviors for HIV infection. Ann Epidemiol. 2004;14:535–42.

    Article  PubMed  Google Scholar 

  83. Buchacz K, McFarland W, Kellogg TA, Loeb L, Holmberg SD, et al. Amphetamine use is associated with increased HIV incidence among men who have sex with men in San Francisco. AIDS. 2005;19:1423–4.

    Article  PubMed  Google Scholar 

  84. Molitor F, Truax SR, Ruiz JD, Sun RK. Association of methamphetamine use during sex with risky sexual behaviors and HIV infection among non-injection drug users. West J Med. 1998;168:93–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  85. Celetano DD, Latimore AD, Mehta SH. Variations in sexual risks in drug users: emerging themes in a behavioral context. Curr HIV/AIDS Rep. 2008;5:212–8.

    Article  Google Scholar 

  86. Kessler RC. The epidemiology of dual diagnosis. Biol Psychiatry. 2004;56:730–7.

    Article  PubMed  Google Scholar 

  87. O’Brien CP, Charney DS, Lewis L, Cornish JW, Post RM, et al. Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action. Biol Psychiatry. 2004;56:703–13.

    Article  PubMed  Google Scholar 

  88. Conway KP, Compton W, Stinson FS, Grant BF. Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2006;67:247–57.

    Article  CAS  PubMed  Google Scholar 

  89. Goodwin RD, Stein DJ. Anxiety disorders and drug dependence: evidence on sequence and specificity among adults. Psychiatry Clin Neurosci. 2013;67:167–73.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, et al. Comorbidity of mental disorders with alcohol and other drug abuse. JAMA. 1990;264:2511–8.

    Article  CAS  PubMed  Google Scholar 

  91. Grella CE, Karno MP, Warda US, Niv N, Moore AA. Gender and comorbidity among individuals with opioid use disorders in the NESARC study. Addic Behav. 2009;34:498–504.

    Article  Google Scholar 

  92. National Center for PTSD. Facts about PTSD. Psych Central; 2006. Available from URL: http://psychcentral.com/lib/facts-about-ptsd/000662 (Accessed 19 September 2013).

    Google Scholar 

  93. Kessler RC, Berglund PA, Demler O, Jin R, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Arch Gen Psychiatry. 2005;62:593–602

    Article  PubMed  Google Scholar 

  94. Mills KL, Lynskey M, Teesson M, Ross J, Darke S. Post-traumatic stress disorder among people with heroin dependence in the Australian treatment outcome study (ATOS): prevalence and correlates. Drug Alcohol Depend. 2005;77:243–9.

    Article  PubMed  Google Scholar 

  95. Reynolds M, Mezey G, Chapman M, Wheeler M, Drummond C, Baldacchino A. Co-morbid posttraumatic stress disorder in a substance misusing clinical population. Drug Alcohol Depend. 2005;77:251–8.

    Article  PubMed  Google Scholar 

  96. Riggs DS, Rukstalis M, Volpicelli JR, Kalmanson D, Foa EB. Demographic and social adjustment characteristics of patients with comorbid posttraumatic stress disorder and alcohol dependence: potential pitfalls to PTSD treatment. Addict Behav. 2003;28:1717–30.

    Article  PubMed  Google Scholar 

  97. Ouimette P, Read JP, Wade M, Tirone V. Modeling associations between posttraumatic stress symptoms and substance use. Addict Behav. 2010;35:64–7.

    Article  PubMed  Google Scholar 

  98. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51:8–19.

    Article  CAS  PubMed  Google Scholar 

  99. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003:289:3095–105.

    Article  PubMed  Google Scholar 

  100. Kessler RC, Crum RM, Warner LA, Nelson CB. Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Arch Gen Psychiatry. 1997;54:313–21.

    Article  CAS  PubMed  Google Scholar 

  101. Grant BF, Stinson FS, Dawson DA, Chou SP, Dufour MC, et al. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2004;61:807–16.

    Article  PubMed  Google Scholar 

  102. Merikangas KR, Herrell R, Swedsen J, Rossler W, Ajdacic-Gross V, Angst J. Specificity of bipolar spectrum conditions in the comorbidity of mood and substance use disorders: results from the Zurich cohort study. Arch Gen Psychiatry. 2008;65:47–52.

    Article  PubMed  Google Scholar 

  103. Dalton EJ, Cate-Carter TD, Mundo E, Parikh SV, Kennedy JL. Suicide risk in bipolar patients: the role of co-morbid substance use disorders. Bipolar Disord. 2003;5:58–61.

    Article  PubMed  Google Scholar 

  104. Hser YI, Lanza HL, Li L, Kahn E, Schulte M. Maternal mental health and children’s internalizing and externalizing behaviors: beyond maternal substance use disorders. Manuscript under review, 2013.

    Google Scholar 

  105. Kessler RC, Chiu WT, Demler O, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:617–27.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Fazel S, Danesh J. Serious mental disorder in 2300 prisoners: a systematic review of 62 surveys. Lancet. 2002;359:545–50.

    Article  PubMed  Google Scholar 

  107. Hare RD. Diagnosis of antisocial personality disorder in two prison populations. Am J Psych. 1983;140:887–90.

    Article  CAS  Google Scholar 

  108. Ford JD, Gelrnter J, DeVoe JS, Zhang W, Weiss RD, et al. Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals. Drug Alcohol Depend. 2009;99:193–203.

    Article  PubMed  Google Scholar 

  109. Mueser KT, Gottlieb JD, Cather C, Glynn SM, Zarate R, et al. Antisocial personality disorder in people with co-occurring severe mental illness and substance use disorders: clinical, functional, and family relationship correlates. Psychosis. 2012;4:52–62.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Gabbard GO, Gunderson JG, editors. Psychotherapy for Personality Disorders. 1st ed. Vol. 19, Review of Psychiatry. Arlington (VA): American Psychiatric Publishing; 2000. p.192.

    Google Scholar 

  111. Patterson TL, Jeste DV. The potential impact of the baby-boom generation on substance abuse among elderly persons. Psychiatr Serv. 1999;50:1184–8.

    Article  CAS  PubMed  Google Scholar 

  112. Yuan Z, Dawson N, Cooper GS, Einstadter D, Cebul R, Rimm AA. Effects of alcohol-related disease on hip fracture and mortality: a retrospective cohort study of hospitalized Medicare beneficiaries. Am J Public Health. 2000;91:1089–93.

    Google Scholar 

  113. Royal College of Psychiatrists. Our invisible addicts: first report of the Older Persons’ Substance Misuse Working Group of the Royal College of Psychiatrists. College Report CR165. London: Royal College of Psychiatrists; June 2011. Available from URL: http://www.rcpsych.ac.uk/files/pdfversion/cr165.pdf (Accessed 4 February 2014).

    Google Scholar 

  114. Bucholz KK, Sheline Y, Helzer JE. The epidemiology of alcohol use, problems, and dependence in elders: a review. In: Beresford TP, and Gomberg E, (editors). Alcohol and Aging. New York (NY): Oxford University Press; 1995. p.19–41.

    Google Scholar 

  115. Reid MC, Anderson PA. Geriatric substance use disorders. Med Clin North Am. 1997;81:999–1016.

    Article  CAS  PubMed  Google Scholar 

  116. Sorock GS Shimkin EE. Benzodiazepine sedatives and the risk of falling in a community dwelling cohort. Arch Intern Med. 1988;148:2441–4.

    Article  CAS  PubMed  Google Scholar 

  117. Field TS, Gurwitz JH, Avorn J, McCormick D, Jain S, et al. Risk factors for adverse drug events among nursing home residents. Arch Intern Med. 2001;161:1629–34.

    Article  CAS  PubMed  Google Scholar 

  118. Sheahan SL, Coons SJ, Robbins CA, Martin SS, Hendricks J, Latimer M. Psychoactive medication, alcohol use, and falls among older adults. J Behav Med. 1995;18:127–40.

    Article  CAS  PubMed  Google Scholar 

  119. Mukamal KJ, Chung H, Jenny NS, Kuller LH, Longstreth WT, et al. Alcohol use and risk of ischemic stroke among older adults: the cardiovascular health study. Stroke. 2005;36:1830–4.

    Article  PubMed  Google Scholar 

  120. Cox JL. Smoking cessation in the elderly patient. Clin Chest Med. 1993;14:423–8.

    CAS  PubMed  Google Scholar 

  121. Mamun AA, Peeters A, Barendregt J, Willekens F, Nusselder W, Bonneux L; NEDCOM, The Netherlands Epidermiology and Demography Compression of Morbidity Research Group. Smoking decreases the duration of life lived with and without cardiovascular disease: a life course analysis of the Framingham Heart Study. Euro Heart J. 2004:25:409–15.

    Article  Google Scholar 

  122. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, et al. SEER cancer statistics review, 1975–2009 (Vintage 2009 populations). Bethesda (MD): National Cancer Institute; 2009.

    Google Scholar 

  123. Adams WL, Yuan Z, Barboriak JJ, Rimm AA. Alcohol-related hospitalizations in elderly people: prevalence and geographic variation in the United States. JAMA. 1993;270:1222–5.

    Article  CAS  PubMed  Google Scholar 

  124. Gramenzi A, Caputo F, Biselli M, Kuria F, Loggi E, et al. Review article: alcoholic liver disease–pathophysiological aspects and risk factors. Aliment Pharmacol Ther. 2006;24:1151–61.

    Article  CAS  PubMed  Google Scholar 

  125. U.S. Department of Health and Human Services. Mental health: a report of the Surgeon General. Rockville (MD): DHHS; 1999. Available from URL: http://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/NNBBHS (Accessed 4 February 2014).

    Google Scholar 

  126. Victor M, Adams RD, Collns GH. The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders due to Alcoholism and Malnutrition (Vol. 30). Philadelphia (PA): FA Davis Company; 1989.

    Google Scholar 

  127. Zuccala G, Onder G, Pedone C, Cesari M, Landi F, et al. Dose-related impact of alcohol consumption on cognitive function in advanced age: results of a multicenter survey. Alcohol Clin Exp Res. 2001;25:1743–8.

    Article  CAS  PubMed  Google Scholar 

  128. Peters R, Peters J, Warner J, Beckett N, Bulpitt C. Alcohol, dementia and cognitive decline in the elderly: a systematic review. Age Ageing. 2008;37:505–12.

    Article  PubMed  Google Scholar 

  129. Blow FC. Substance Abuse among Older Adults: Treatment Improvement Protocol (TIP). Rockville (MD): USDHSS/PHS/SAMHSA Center for Substance Abuse Treatment; June 2001.

    Google Scholar 

  130. Simoni-Wastila L, Yang HK. Psychoactive drug abuse in older adults. Am J Geriatr Pharmacother. 2006;4:380–94.

    Article  PubMed  Google Scholar 

  131. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc. 1999;47:30–9.

    Article  CAS  PubMed  Google Scholar 

  132. King-Kallimanis B, Gum AM, Kohn R. Comorbidity of depressive and anxiety disorders for older Americans in the national comorbidity survey-replication. Am J Geriatr Psychiatry. 2009;17:782–92.

    Article  PubMed  Google Scholar 

  133. Pedersen T. Depression, anxiety ups addiction among older Americans. Psych Central; 18 April 2012. Available from URL: http://psychcentral.com/news/2012/04/18/depression-anxiety-ups-addiction-among-older-americans/37483.html (Accessed 2 July 2013).

    Google Scholar 

  134. National Institute of Mental Health Online. NIH Senior Health. About anxiety disorders: anxiety disorders in older adults. 2010. Available from URL: http://nihseniorhealth.gov/anxietydisorders/toc.html (Accessed 2 July 2013).

    Google Scholar 

  135. Blow FC, Brockmann LM, Barry KL. Role of alcohol in late-life suicide. Alcohol Clin Exp Res. 2004;28:48–56.

    Article  Google Scholar 

  136. Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, RTI International. The NSDUH report: illicit drug use among older adults. Rockville (MD): Center for Behavioral Health Statistics Quality and SAMHSA; 1 September 2011. Available from URL: http://www.samhsa.gov/data/2k11/WEB_SR_013/WEB_SR_013_HTML.pdf (Accessed 4 February 2014).

    Google Scholar 

  137. Compton WM, Thomas YF, Stinson FS, Grant BF. Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States. Arch Gen Psychiatry. 2007;64:566–76.

    Article  PubMed  Google Scholar 

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  1. UCLA Integrated Substance Abuse, University of California, Programs 11075 Santa Monica Blvd., Suite 200, Los Angeles, CA, 90025, USA

    Marya T. Schulte PhD & Yih-Ing Hser PhD

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Schulte, M.T., Hser, YI. Substance Use and Associated Health Conditions throughout the Lifespan. Public Health Rev 35, 3 (2013). https://0-doi-org.brum.beds.ac.uk/10.1007/BF03391702

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